Rampage (2018)
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Athena-1, a space station owned by gene-manipulation company Energyne, is destroyed after a laboratory rat mutates and wreaks havoc.
Dr. Kerry Atkins, the lone surviving crew member, is ordered by Energyne CEO Claire Wyden to retrieve canisters containing a pathogen. Atkins flees in the escape pod when the station implodes, but it disintegrates upon re-entry, killing her and leaving a trail of debris across the United States. One canister is swallowed by an American crocodile in the Everglades, and another lands in a Wyoming forest where a wolf is exposed to the pathogen.
Primatologist Davis Okoye, a former US Army Special Forces soldier and member of an anti-poaching unit, works at the San Diego Wildlife Sanctuary. He has befriended a rare albino western lowland gorilla named George, having saved it from the poachers who killed his mother, and communicates with George using sign language. One of the canisters crash-lands in George's habitat, and George is exposed to the pathogen.
As George grows considerably larger and more aggressive, Davis is contacted by genetic engineer Dr. Kate Caldwell, who explains that the pathogen was developed by Energyne to rewrite genes on a massive scale. She had hoped to advance CRISPR research as a potential cure for diseases, but discovered Energyne's plans to use it as a biological weapon, and was fired and falsely sent to prison, resulting in the death of her terminally ill brother. George escapes from captivity and goes on a rampage at the preserve. He is calmed, but George is captured by a government team led by Agent Harvey Russell and put on an airplane. Meanwhile, Claire and her brother Brett oversee a mercenary team's attempt to capture the mutated wolf, Ralph, which ends in failure and the slaughter of the entire team.
Claire, hoping to capture Ralph and use George to cover up her plot, uses a massive transmitter atop the Willis Tower to lure the animals – engineered to respond aggressively to a certain radio frequency – to Chicago, unconcerned about the massive risk to civilian lives this poses. George reacts violently to the sound and crashes the plane, though Davis, Kate, and Russell parachute to safety. George survives the crash and joins Ralph as they make their way to Chicago, and Davis and Kate are aided by Russell in stealing a military helicopter in pursuit.
They arrive to find George and Ralph tearing through the city as the military struggles to contain them. The situation worsens when the mutated crocodile, Lizzie, joins the duo, causing even more casualties. Planning to steal a counter-serum to turn the mutated animals back to normal, Davis and Kate infiltrate Energyne's base of operations at the Willis Tower and take several vials of the serum, but are caught by Claire and Brett. Claire reveals that the serum only eliminates the animals' enhanced aggressiveness rather than revert them to their normal size, and shoots Davis, but he survives. When George climbs to the top of the tower, Claire orders Davis to distract it while she attempts to escape with Kate at gunpoint. Kate slips a vial into Claire's handbag and pushes her toward George, who eats Claire, crushing her along with the serum, returning him to his normal personality. Below, Russell takes incriminating evidence from Brett, who is crushed to death by falling debris. As the damaged tower topples, Davis and Kate survive by crash-landing a helicopter on Federal Plaza.
Davis stays in the city to help George defeat the other two monsters, while Kate and Russell rush to prevent the military from deploying a MOAB against the creatures. George fights Ralph, whom Davis tricks into flying towards Lizzie, who decapitates him using her jaws. Lizzie chases Davis, but George intervenes in time for Davis to incapacitate the crocodile with grenades. However, Lizzie survives and overpowers George, who is impaled by a rebar. Davis distracts Lizzie using a fallen Apache attack helicopter, but is nearly killed before George stabs Lizzie through the eye with the same rebar, killing her.
With the threat neutralized, the airstrike is aborted. In the aftermath, George and Davis, joined by Kate and Russell, help clear the city of debris and rescue civilians.